Methods

Our portfolio of primary (community) and secondary (hospital) care trials include: 

• Targeted screening for Barrett’s oesophagus and surveillance for those with non-dysplastic Barrett’s oesophagus to improve oesophageal cancer outcomes e.g. BEST4 Screening and Surveillance trials

• Multi-cancer early detection (MCED) test in screening and early detection e.g. NHS Galleri

• Medicinal prevention (of prostate cancer in particular) often using drug re- purposing e.g. FINESSE

• Psychological and behavioural impact of screening uptake and cancer prevention e.g. SPOTLIGHT

• Smoking cessation (psychological and pharmacological interventions including e- cigarettes) e.g. VAPELINE

• Pragmatic trials of screening interventions e.g. cervical self-sampling and faecal Immunochemical testing (FIT) in Lynch patients

• Long-term follow-up of participants from successful RCTs (of breast cancer prevention and treatment in particular); 

• Bio-specimen collections for biomarker discovery and validation.