Cancer prevention for indolent cancers and pre-cancers
FINESSE
FINESSE: A randomised phase 3 trial evaluating the role of Finasteride in increasing compliance with Active surveillance, in men with a new diagnosis of low and intermediate risk prostate cancer, when compared with usual care
Full portfolio adoption and currently recruiting.
For further info, please see the trial website or ISRCTN registry.
NOVEL
NOVEL: Nonavalent prophylactic HPV vaccine (GARDASIL® 9) after local conservative treatment for cervical intra-epithelial neoplasia (CIN)
Partial portfolio adoption (statistical support only) and undergoing analysis.
Further info:
ClinicalTrials.gov.
Cancer early diagnosis
NHS-Galleri
NHS-Galleri: Does screening with the Galleri test in the NHS reduce the likelihood of a late-stage cancer diagnosis?
Full portfolio adoption and in passive follow-up.
Further info: trial website or ISRCTN registry.
BEST4 Screening Trial
BEST4 Screening Trial: Assessing the use of a capsule sponge device as a screening tool to identify signs of the precancerous condition Barret's oesophagus in patients with heartburn, acid reflux and indigestion symptoms
Full portfolio adoption and currently recruiting.
Further info: trial website or ISRCTN registry.
BEST4 Surveillance Trial
BEST4 Surveillance Trial: Using the capsule sponge test in surveillance of Barrett’s Oesophagus.
Partial portfolio adoption (statistical support) and currently recruiting.
Further info: trial website or ISRCTN registry.
BC-Recon
BC-Recon: Diagnosing Bladder Cancer- evaluating the role of a urinary biomarker test in the Reconfiguration of the haematuria clinic investigations.
Partial portfolio adoption (quality management input) and currently recruiting.
Further info: ISRCTN registry.
Cancer screening
YORKSURe
YORKSURe: Early detection of bladder cancer in Yorkshire: Feasibility assessments for implementing a targeted study in populations with high disease specific mortality risk
Full portfolio adoption and currently in passive follow-up.
Further info: ISRCTN registry.
Fit for Lynch
FIT for Lynch: Exploring the utility and acceptability of Faecal Immunochemical Testing (FIT)
as a novel intervention for the improvement of Colorectal Cancer (CRC) surveillance in individuals with Lynch Syndrome
Partial portfolio adoption (statistical and database support) and currently in follow-up.
Further info:
ISRCTN registry.
Smoking cessation
VAPELINE
VAPELINE: Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?
Partial portfolio adoption (statistical and database support) and in active follow-up.
For further info, please see the
ISRCTN registry.
SCeTCH
SCeTCH: Effects of e-cigarettes vs usual care for smoking cessation when offered at homeless centres: A cluster randomised controlled trial
Partial portfolio adoption (database support) and dissemination underway.
For further info, please see the
ISRCTN registry.
Behavioural science